ABSTRACT

Swietenia mahagoni Linn. is a commonly used herb in Ayurvedic medicine. This review supports all updatedinformation on its phytochemical andpharmacological activities, traditional uses and scientific approach. The plant extracts andits chemical marker or target molecule limonoids like swietenolide, have been widely used for the treatment of a large number ofhuman ailments. The chemical entities of this plant has been used as Antibacterial activity, Antimicrobial Activity, Antioxidantactivity, Anti ulcer activity, Antifungal activity, Anti – HIV activity, Anti-inflamatory, Analgesic and Antipyretic activity,Hypoglcemic activity, Platelet Aggregation Inhibitors activity etc. Scientifically proved activities are related with traditionalconcept. Scientific evidence exists with respect to their major and minor constituents. Swietenia mahagoni Linn is one of themost important controversial and effective natural origin that has a tremendous future for research. The novelty and applicabilityof Swietenia mahagoni Linn. are hidden Such things should be overcome through modern scientific concept.

Key words: Swietenia mahagoni Linn, swietenolide, Pharmacological activities.

ABSTRACT

Angiogenesis indicates process of growth of blood vessels and an imbalance leads to melignancy, infections, ischaemiaetc. In angiogenesis, the vascular network expands by sprouting and remodels to several organized system of large vessels andsmaller ones. Vascular and lymphatic EC sprouting can be regulated by VEGF and PIGF (a homologue of VEGF). Now-a-daysangiogenesis can be inhibited by targeting different cells like mural, stromal, endothelial and haematopoetic cells. Some antiangiogenicagents like VEGF antibody “AVASTIN” and RTKIs Which targets the VEGFR like receptors and arrests ECproliferation and prevents vessel growth. Sometimes combination of VEGF inhibitors with other inhibitors of distinct targets canincrease the efficacy. When the mural cell and stromal cells are targeted, local release of VEGF and angiopoetin 1 occurs, andthat may leads to tumor growth when PDGF signaling is over expressed. Therefore PDGFRβ signaling is inhibited and tumorvessels are dilated and EC apoptosis increased. These PDGFRβ inhibitors also destabilize SMCs which supply bulk flow totumors making them susceptible to EC inhibitors. On the other hand PDGF-BB antagonists lower the intestinal fluid pressure &improve drug delivery through the tumor vasculature. In the recent future, the treatment of cancer will involve the use ofcytotoxic radiation to destroy the malignant cells. Tumor cell angiogenesis may also be inhibited directly by targeting cells and itmay lead to vessel decompression resulting in increased perfusion & drug delivery.

Keywords: Angiogenesis, VEGF, PDGF, mural and stromal cell, neurodegeneration.

ABSTRACT

To develop a simple, rapid, sensitive, accurate, precise and reproducible high performance liquid chromatographicmethod for the determination of Darunavir in tablet dosage form. Waters, Symmetry shield RP18 (250X4.6mm, 5μm) column,0.1% orthophosphoric acid and acetonitrile (50:50 % v/v) as mobile phase, detection wavelength of 265 nm, flow rate of 1.0 mLmin-1. The method is linear from 25μg mL-1 to 100μg mL-1, accuracy was found to be 99.54%, mean inter and intraday assayrelative standard deviation (RSD) were less than 1.0%. The method is simple, accurate, specific and precise, can be used for thedetermination of Darunavir.

Key words: Darunavir, antiretroviral, reversed-phase and validation

ABSTRACT

The present study was under taken to investigate effect of Remusatia vivipara (roxb.) schott (RV) tubers on Animalmodel of Depression by using Tail Suspension (TST), Forced Swim Test (FST) and Actophotometer. The ethanolic extract ofRemusatia vivipara (roxb.) schott (100 and 200 mg/kg, p.o.) and Imipramin (10 mg/kg, i.p.) was administered in Swiss albinomice 30 min before experiment. The result indicates, significantly increases duration of immobility in TST and FST while itshowed significant CNS depression by reducing locomotor activity in mice. Thus, in conclusion the ethanolic extract ofRemusatia vivipara (roxb.) schott has potent CNS depression action.

Keywords: Remusatia vivipara, Depression, Tail Suspension Test, Forced Swim Test, Actophotometer.

Abstract

Tuberculosis (TB), widely occurring, is still one of the most deadly infectious diseases worldwide. Rifampicin is a wellknowncandidate for its excellent antitubercular activity. But it suffers from such many drawbacks as a poorly soluble drug, shorthalf-life, severe adverse effects of the drugs during long-term therapy, pH-dependent degradation, potential bioavailabilityproblems associated with drugs, and poor patient compliance. Design and development of controlled release (CR) formulationshas been and continues to be of greater interest to formulation scientists and pharmaceutical industry. They offers manyadvantages, such as improved patient compliance, less dose, minimized side effects, reduced or no fluctuation of drug in theblood, and cost effectiveness. Therefore in this present research work, an attempt was made to formulate and characterizehydrophilic controlled release matrix tablets of rifampicin have been formulated using Hydroxypropyl methylcellulose (HPMC)polymer (medium and high viscosity) by direct compression method. Influence of formulation variables such as drug: HPMCratio, viscosity grade of HPMC on the formulation characters and drug release has been studied. Our results indicated that therelease rate of the drug and the mechanism of release from the HPMC matrices are mainly controlled by the drug: HPMC ratioand viscosity grade of the HPMC. The formulations were found to be stable and reproducible.

Keywords: Controlled release matrix tablet, Rifampicin, HPMC, Tuberculosis.