Nano-emulsions are a novel type of emulsions that are distinguished by their homogeneous and extremely tiny droplet sizes,
often in the range of 20–200 nm. When exposed to aqueous media under conditions of gentle agitation or digestive motility
that would be countered in the GIT, self-emulsifying drug delivery systems (SEDDS) are defined as isotropic mixtures of
lipid/oil, surfactant, co-surfactant, and drug substance that rapidly form a fine oil-in-water micro (SNEDDS) and nano
(SNEDDS) emulsions. To increase the oral bioavailability of hydrophobic/lipophilic medicines, SNEDDS is one of the most
promising strategies for overcoming formulation challenges associated with dissolution/solubility. The purpose of this study is
to create and evaluate the SNEDDS of Sulindac ophthalmic emulsion in vitro. The SK9 formulation demonstrated promise. All
of the foregoing data demonstrated a significant increase in Sulindac's bioavailability and solubility when administered in the
form of Oral SNEDDS. Finally, it was determined that SNEDDS is a potential method for increasing the solubility, dissolving
rate, and bioavailability of medicines when administered via the ocular route
