ABSTRACT Patients’ satisfaction has long been considered as an important component when measuring health outcome and quality of care. The objective of this paper is to study expectations and satisfactions of patients attending UHC, Chidambaram. Data were collected from outpatients at UHC, Chidambaram through pre structured questionnaire. Data were analyzed statistically. A total of 200 patients were interviewed in this study to find out their expectations and satisfactions from the doctor. It was found that most of respondents were women and studied up to secondary level. Patients were fully satisfied in areas such as politeness and kindness of the doctor. Key words: Expectations, Satisfaction, Doctor.

ABSTRACT Snake bite is a neglected public health problem distributed mainly in tropical and sub-tropical countries. India is one of the highest prevalent countries. To describe the clinico-epidemiological profile and outcome of the snake bite cases admitted in Rajah muthiah medical college and hospital. All the snake bite cases admitted in the accident and emergency unit between January 2010 to December 2013 (4 years) were analysed using secondary data from Medical records division (MRD). Out of 272 snake bite cases, 64% were referred cases.49.8% were in the age group of 21-50 years, 60.2% were males. Most of the victims (54.4%) were agricultural workers. Peak incidence was observed during rainy season (Aug-Nov). Bite marks were seen in 46.7% of the cases, lower extremity being the commonest site of bite (60%). Out of the 272 envenomation, 51% were unidentified bites, 42% were poisonous bites and 7% were non-poisonous bites. Major complications were cellulitis (42.9%), respiratory failure (20.1%), and eye problems (18.2%). Mean number of ASV vials given was 15.7. Majority (77.5%) recovered. Mortality was found to be 4.5%. Snake bite is an occupational hazard among farmers and need to get more attention. Key words: Clinico-epidemiological profile, Snake bite, Envenomation.

ABSTRACT

In recent years Dengue infection related metabolic disturbances particularly in liver is on the increase. Data available from research on Dengue related diseases mainly point out alterations in liver enzymes, notably transaminases. This research article is an attempt to find out the association between liver function tests in dengue infected patients in comparison with controls. Among the liver function tests significant associations were found between patients and controls for Bilirubin fractions, ALT and GGTP but not for AST as ALT is more liver specific than AST.

Key words: Dengue, Dengue Infection, ALT, AST.

ABSTRACT The rise in caesarian section is now a matter that deserve international attention. To find out the frequency, indication and the factors associated with LSCS in RMMCH for one month period. A descriptive study was done using secondary data from medical record division of RMMCH. Out of 344 deliveries conducted during one month, 54.65% was found to be LSCS. 52% were in the age group of 21-25 years. 38.57% of LSCS was done for primigravida and 20.71%was repeat LSCS. 8.57% of LSCS was done without any indications. Caesarian section has become so common procedure in the practice of modern obstetrics.

Key words: Caesarian section, Secondary data, Indications.

ABSTRACT

Asclepias curassavica was used traditionally in different populations for many medical complains. It contained a widerange of chemical constituents including flavonols, flavonol glycosides, amino acids, carbohydrates, triterpenes, cardenolidesand many other biologically active compounds. The cardenolides isolated from the plant included calactin, calotropin,calotropagenin, coroglaucigenin, asclepin, asclepain CI, asclepain CII, asclepine (asclepiadin), uscharidin, uzarin, uzarigenin,corotoxigenin, asclepogenin, curassavogenin, calotroposide, clepogenin, desglucouzarin, kidjolanin, and uscharidin. Theprevious studies showed that the plant exerted many pharmacological activities including antimicrobial, anticancer,cardiovascular, analgesic and antipyretic and many other pharmacological activities. This paper is a step ahead to open a newinsight for the therapeutic efficacy of Asclepias curassavica.

Key words: Asclepias curassavica, Pharmacology, Constituents.

ABSTRACT

Artemisia campestris contained alkaloids, saponins, terpenes and flavonoids. The hydrodistilled essential oil of fresh aerial parts of Artemisia campestris contained β-myrcene (16.47%), α-pinene (14.18 %), trans-β- ocimene (12.61%), β-cymene (8.15%) and camphor(5.85%). A. campestris, revealed several pharmacological activities such as antimicrobial, antioxidant, cytotoxic, insecticidal, antivenomous and many other pharmacological effects. The present review will highlight the chemical constituents and the pharmacological and therapeutic effects of Artemisia campestris.

Key words: Artemisia campestris, Pharmacology, Contents.

ABSTRACT Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is an area of uncovered bone in the maxillo-facial region that did not heal within 8 weeks after identification by health care provider, in a patient who was receiving or had been exposed to Bisphosphonate Therapy (BPT) without previous radiation therapy to the craniofacial region. The management of BRONJ currently is a dilemma. No effective treatment has yet been developed and interrupting BPT does not seem to be beneficial. Temporary suspension of BPs offers no short-term benefit, whilst long term discontinuation (if systemic conditions permit it) may be beneficial in stabilizing sites of ONJ and reducing clinical symptoms. The use of oral antimicrobial rinses in combination with oral systemic antibiotic therapy -penicillin, metronidazole, quinolones, clindamycin, doxycycline, and erythromycin- is indicated for Stages I and II of Ruggiero's Staging. The role of hyperbaric oxygen therapy is still unclear but some benefits of this treatment have recently been described in association with discontinuation of BPT and conventional therapy (medical or/and surgical). Surgical debridement or resection in combination with antibiotic therapy may offer long-term palliation with resolution of acute infection and pain. Mobile segments of bony sequestrum should be removed without exposing unaffected bone. Ozone therapy in the management of bone necrosis or in extractive sites during and after oral surgery in patients treated with BPs may stimulate cell proliferation and soft tissue healing. Key words: Osteoradionecrosis, Jaw, Bisphosphonate, Chemotherapy.

ABSTRACT Attention deficit/hyperactivity disorder (ADHD) is the commonest neurodevelopmental disorder of children. The present study was conducted to evaluate the effectiveness of traditional Ayurvedic formulation „Saraswatarista‟ in the management of pediatric attention deficit hyperactivity disorder. Children aged 07-13 years suffering from ADHD were screened out from OPD of PG Department of Gopabandhu Ayurveda Mahavidyalaya, Puri and from various schools situated in Puri by survey method. Patients were randomized into two groups. Group A (15 patients) received Traditional Ayurvedic formulation „Saraswatarista‟ (01ml/kg/body weight in divided dose) and group B received placebo syrup (01ml/kg/body weight in divided dose) for a period of 12 weeks. All the patients were subjected to thorough baseline screening and followed by assessment through NICHQ Vanderbilt assessment scale – parent‟s informant and NICHQ Vanderbilt assessment scale – teacher‟s informant. Group A patients showed highly significant (P<.001) improvement in overall scholastic performance, Participation in Organized Activities, Writing Skills, Mathematical Aptitude, Relationship with Parents, Relationship with Siblings, Relationship with Peers and Reading Ability while in group B the change from baseline was statistically not significant with p > 0.05. No adverse event was evident during the study period. Thus, Saraswatarista is found to be effective in managing Attention deficit/hyperactivity disorder (ADHD) by reducing the severity of core symptoms as evident by improvement in various assessment parameters. Key words: Ayurveda, Saraswatarista, ADHD.

ABSTRACT Diabetes mellitus is a common endocrine disorder that affects more than 180 million people worldwide and this number is expected to rise to 366 million by the year 2030. Though different types of oral hypoglycemic agents are available along with insulin for the management of diabetes mellitus, they are associated with undesirable side effects. Therefore, there is an increasing demand of safer anti-diabetics especially from natural sources. Mushrooms are exemplary sources of natural medicines with antidiabetic potential. They serve as an ideal choice for diabetic patients owing to their high content of fiber and protein along with low fat content. Mushrooms are regarded as functional foods and are also important sources of bioactive compounds which include high molecular weight compounds such as polysaccharides, proteins and lipids as well as a number of low molecular weight metabolites such as lectins, lactones, terpenoids, alkaloids, sterols and phenolic substances which are responsible for the therapeutic activity. The present review describes the anti-diabetic role of mushrooms in experimental and/or clinical studies. Published literature demonstrates that mushrooms have immense potential and may be developed as effective and safe anti-diabetic therapy. Key words: Diabetes mellitus; Anti-diabetic agents; Medicinal mushrooms.

ABSTRACT A new simple, rapid, accurate, sensitive and precise spectrophotometric method in ultra violet region has been developed for determination of Valizodone in pure and tablet dosage form. Valizodone exhibited maximum absorbance at 241 nm in methanol. Beer's law was found to be obeyed in the concentration range 2-10 μg mL-1. Correlation coefficient was found to be 0.999. The developed method was validated respect to linearity, precision, accuracy. The proposed method is useful for the routine estimation of Valizodone in pure and tablet dosage form. Key words: Valizodone, UV estimation, Validation.

ABSTRACTTo assess the risk factors for medical treatment failure and requirement of surgical treatment for tubo-ovarian abscess(TOA). The patients with tubo-ovarian abscess were recruited between 2012 and 2014, retrospectively. Age, obstetric history,menopausal status (non-menopausal vs menopausal), clinical and sonographic presentation, pelvic inflammatory design riskfactors, antibiotic therapy, surgical treatment, time interval between hospitalization and surgery, presence of complications,laboratory results, and length of hospital stay were examined. We detected 52 patients with prediagnosis of tubo-ovarianabscess were hospitalized. After hospitalization, TOA was ruled out in 11 patients. 41 patients were reviewed. Ten (24, 3%)patients underwent surgical treatment because of failed antibiotic therapy. Thirty-one (75, 7%) patients treated successfullywith parenteral antibiotic. The mean age of surgically treated patients was significantly higher than medically treated patients(p=0.048). Number of gestations and abortions were higher in patients who needed surgery (p=0,032 and p=0,037). It was alsoseen that abscess volume, C-reactive protein (CRP) levels and erythrocyte sedimentation rate (ESR) were also higher insurgically treated patients (p=0,004; p=0,010 and p=0,036, respectively). Mean duration of hospitalization was significantlylonger in patients treated surgically (p=0,017). According to the ROC analysis, CRP level, abscess volume and abscess size areuseful to predict the outcome of TOA treatment with antibiotics. Medical treatment failure and need of surgery are morecommon in patients who have large abscess (volume:>60 cm3 or size: >5cm), elevated CRP levels (>6,7 mg/L) and high ESR(>50 mm/hr).Key words: Medical treatment, Risk factor, Surgical treatment, Tubo-ovarian abscess

ABSTRACT Advanced glycation end products are a group of biochemical species formed by the chronic exposure of vital biomolecules to hyperglycemia. All events leading to diabetic retinopathy such as, adhesion of leukocytes and monocytes to capillary endothelial cells, apoptosis of endothelial cells and pericytes, dismantling of blood retinal barrier, increased expression of pro-angiogenic factors and decreased the expression of anti-angiogenic factors in the retinal endothelial cell are linked to an increased formation of advanced glycation end products. Expression of receptors for the advanced glycation end products and its gene polymorphism are found to have a major implication in the development and progression of diabetic retinopathy. Soluble extracellular ligand binding domains of these receptors called as sRAGEs that circulate freely in plasma are shown to scavenge advanced glycation end products and prevent damages. So there lies a large scope for research with respect to the role of sRAGE in the treatment and management of diabetic retinopathy. Key words: Diabetic retinopathy, advanced glycation end products, receptors for advanced glycation end products, angiogenesis.