ABSTRACT The technique of liquisolid compacts is a promising method towards enhancing the dissolution of poorly water soluble drugs. In the liquisolid formulation, avicel PH 102 was used as carrier and aerosil was used as coat material, respectively, and polyethylene glycol 600 was used as a nonvolatile liquid to prepare liquid medication. This review article is focused on formulation of liquisolid systems, classification of liquid solid systems and its applications in the field of pharmaceutical sciences. Key words: Liquisolid, Liquid medication, Formulation.

ABSTRACT

An asthma spacer is an add-on device used to increase the ease of administering aerosolized medication from a metered-dose inhaler (MDI). Asthma inhalers can deliver drugs in a variety of ways. Metered dose inhalers (MDIs) provide the drug through a small, handheld aerosol canister, dry powder inhalers requirebreathe in quickly and deeply, nebulizer deliver medication through a mouthpiece or mask. This article explain about the use of spacer in meter dose inhaler, its benefit and disadvantage. 

Key words: Meter dose inhalers(MDIs), Dry powder inhalers(DPIs).

ABSTRACT C. colocynthis contained carbohydrate, protein, separated amino acid, tannins, phenolics, flavanoids, glucosides, terpenoids, alkaloids, anthranol, steroids, cucurbitacins, saponin, cardic glycoloids, trace elements and many other chemical groups. It possessed antioxidant, Antidiabetic, antimicrobial, anticancer, anti-inflammatory, analgesic, gastrointestinal, reproductive and protective and many other pharmacological effects. This paper will highlight the phytochemical screening, antibacterial studies, GCMS and FT-IR studies of C. colocynthis. Key words: C. colocynthis, preliminary phytochemical, antibacterial, GCMS and FT-IR.

ABSTRACT The purpose of research work was to study revalidation for Zolpidem tartrate 5 mg film coated tablets. Quality cannot be adequately assured by in-process and finished inspections and testing but it should be built in to the manufacturing process. These processes should be controlled in order or finished product meets all quality specifications. The critical process parameters were identified with the help of process capability and evaluated by challenging its lower and upper release specification. Three initial process validation batches (A, B, C) of same size, method, equipment and validation criteria were taken. The critical parameter involved in sifting , dry mixing, preparation of granulating agent, wet mixing, wet milling, drying, sizing, lubrication, compression stages and coating were identified and evaluated as per validation plan. Film coating of tablets were evaluated for coating uniformity, coating process efficiency and surface roughness. The spray rate, atomization air pressure, inlet air temperature, distance of nozzle from tablet bed, pan speed and pan differential pressure these affect the final film quality of coated tablets. Outcome indicated this process validation data provides high degree of assurance and manufacturing process produces product meeting its predetermined specifications and quality attributes. Key words: Zolpidem tartrate, Coated tablet, Process validation, Process parameters.

ABSTRACT Abnormal vaginal bleeding (AVB) is considered as one of the most common and perplexing problems both to the patient and the gynaecologists. Objective: To find out the profile of abnormal vaginal bleeding and health seeking behavior among women of 20 yrs of age and above in Chidambaram. Field practice area under Rajah Muthiah Medical College was conveniently selected for this study. A pretested proforma was used to collect the details regarding socio demographic variables, bleeding pattern and health seeking behavior and analyzed with descriptive statistics. Magnitude of AVB was found to be 12.34% among women of 20 yrs and above.75.72% had irregular menstrual cycles .Oligomenorrhoea was the most common clinical symptoms identified followed by menorrhagia. Conclusion: Though AVB is more common among this population, less than 50% only seek health care. Key words: Abnormal vaginal bleeding, Menstrual irregularities, Oligomenorrhoea, Menorrhagia.

ABSTRACT An investigation was carried out to study the soil properties at the Mungeli. The main objectives of this study is to collect information of soil type ,slope ,acidity viz. of the soil causes trace element deficiencies ,N,P, and K deficiencies, to study the physical ,and chemical properties, to know what soil pH & conductivity is and how it is calculated, Crop fertility, Understand and analyze the soil quality of Mungeli. For this study 5 sampling points were selected those are Rampur, Khamria, Mungeli city, Rasali and Tamapar. In this study we observed that Maximum Matasi Soil Samples of Mungeli have low water retention capacity & low fertility status. Conductivity based on salt ion mobility of soil. A decrease in the pH value decreases E.C. or any change in pH value induces a change or variability in the E.C With the help of this study we found the pH & conductivity of the soil. Moreover we also get to know about the nature of the soil (acidic or basic) and the type of ions found in it. So we concluded that the pH of this area is mainly below 6.5 to 8.5. This causes soil acidity and low productivity, whereas electrical conductivity of this area is mainly below to 1, which are well within the limit for the normal crop growth and it suggests that soil is not salty. Key words: Element deficiencies, Conductivity, Crop fertility, Electrical conductivity, productivity.