ABSTRACT

Ayurveda (Indian system of medicine) is the world oldest known medical system. This is very amazing truth that when other civilizations were in infancy phase, Indian system of medicine was at its maturity phase. From the decades this science is serving humanity successfully with its time tested and eternally fundamentals. Even today it comprises the world second most reliable and used complementary and alternative medicine. Thus the fundamentals of this life science should be explore and reestablished on the parameters of present medical science or their clinical validation should be established for its easy access ability and enrichment.

Key words: Ayurveda, Agni, Clinical assessment parameter.

ABSTRACT

Calcium channel blockers (CCBs) are the most commonly prescribed drugs for the treatment of cardiovascular diseases; they produce their effect by blocking the transmembrane calcium influx through calcium channels. Calcium is vital in many biological processes including hormonal secretion, mitosis, reproduction, fertility, and regulation of gene expression. Thus, when CCBs are used for cardiovascular conditions they might affect calcium ion concentration at these sites including the endocrine glands and the hormones secreted by them. Therefore this study was undertaken to elucidate the effects of CCBs on serum testosterone levels in male albino rabbits. Serum Testosterone levels were taken at the commencement of the study as control values This study was performed on thirty male albino rabbits. The rabbits were divided into three groups of ten each. Each group received one of the calcium channel blocker- Verapamil, Diltiazem or Nifedipine for three months continuously. At the end of each month the serum testosterone levels were evaluated by chemiluminiscence and these levels were compared with control values. On daily administration of CCBs for three months serum testosterone levels were lowered in comparison to the control values. Calcium channel blockers are prescribed very commonly and this study proposes the importance of monitoring serum testosterone hormone levels in patients receiving these drugs for long-term since the fall in serum testosterone levels brought about by this group of drugs may have serious clinical implications.

Key words: Calcium channels, Calcium channel blockers, Testes, Testosterone.

ABSTRACT

The aim of present work was to identify and examine the effects Ficus exasperata leaf extract on some physiological parameters that contribute significantly to the success of childbirth. According to previous studies, this plant extract has utérotonic, hypotensive, antihypertensive, anxiolytic, anticonvulsant, anti-inflammatory, analgesic and antipyretic activities which could facilitate labor. In conclusion, Ficus exasperata (Moraceae) has some pharmacological properties thus supporting its folkloric use to facilitate childbirth in parturient women.

Key words: Ficus exasperata, Childbirth, Parturient women.

ABSTRACT

The hepatoprotective plants are capable of curing liver ailments. These herbal Plants have the phyto constituents such as phenyl compounds, coumarins, essential oils, terpenoids, monoterpenoids, diterpenoids, triterpenoids, steroids, alkaloids and other nitrogenous compounds. The plant taken for this study is Aphanamixis polystachya (Wall) Parker. It is called Rohituka in Sanskrit, malampuluvan in Tamil. This plant belongs to Meliaceae family. Its seed and bark are used medicinally. Its habitat is Western Ghats in Thirunelveli district. This plant is used for liver disorders, rheumatoid arthritis, leucorrhoea and anthelmintic ulcers. There has not been sufficient scientific study on hepatoprotective activity of this plant. The scope of the study on bark of Aphanmixis polystachya includes phytochemistry. The finding in phytochemistry is that this plant contains flavonoid in major quantities.

Key words: Aphanmixis polystachya, Hepatoprotective activity, Flavonoid, 5, 4-Dihydroxy 6,8-dimethoxy 7-O-rhamnosyl flavone.

ABSTRACT

The present research work attempted to formulate and evaluate the floating tablet metoprolol succinate. Floating drug delivery system mainly aims at increase in drug gastric retention time. Metoprolol succinate is ß2 selective blocking agent which is used in management of hypertension. Metoprolol succinate floating drug delivery system was prepared using natural polymers like guar gum, xanthan gum and gas forming agent Sodium bicarbonate. Tablets were using directly compression and were evaluated for buoyancy test, swelling study, drug content and In Vitro release profile. The prepared tablets showed acceptable physicochemical characteristics. All the prepared batches showed fine In Vitro buoyancy. The drug release kinetic study was carried out and most of the batches follows korsmeyer peppas model. The formulations had shown significant result with increased concentration. The singular polymer comparison of guar gums had shown more consistent release than xanthan gum. The most optimized result obtained in combination batch of both polymers.

Key words: Floating drug delivery system, Natural polymers.

ABSTRACT

Tagetes erecta is a plant of great medicinal value and is in high commercial demand due to its various uses in religious purposes, as eatables, and is used for the treatment of headache and strengthening of the heart, treating wounds and prevent them from getting infected with bacteria and toxins. Young tender leaves of T.erecta were collected from plants grown in pots under adequate sunlight and rainfall. Leaves were sterilised with 70% ethanol for 5 minutes and 0.02% Mercuric chloride for 3 minutes and inoculated in MS medium supplemented with Kn, IAA, NAA and 2,4-D in different combinations (0, 0.5, 2.5, 5.0, 10 mg/L). 50% callus formation are observed in 0.5 mg/L Kn from LT, 0.5 mg/L Kn + 2.5 mg/L IAA from LM, 0.5 mg/L Kn + 10.0 mg/L IAA from LM, 2.5 mg/L Kn + 0.5 mg/L IAA from LT, 5.0 mg/L Kn + 2.5 mg/L 2,4-D from LT and 10.0 mg/L Kn + 0.5 mg/L IAA from LM. 100% callus formation occurred in the combinations of 0.5 mg/L Kn + 5.0 mg/L 2,4-D from LB and LM, 2.5 mg/L Kn from LT and 5.0 mg/L Kn + 0.5 mg/L IAA from LT. Root formation was observed in the concentration of 2.5 mg/L Kn + 0.5 mg/L IAA from LT. Root formation was observed in low concentration of Kn in combination with low concentration of cytokinin. Callus induction resulted in high concentration of Kn and cytokinin.. It has also been observed that the explants responded differently towards different growth regulators in varying concentrations. The best callus growth was found using the Kn and IAA as growth regulators within a short time period.

Key words: Tagetes Erecta, Growth Regulators, Toxins.

ABSTRACT

Problems of swallowing and provides a quicker onset of action overcomes by fast dissolving tablets constitute an innovative excipients. The bioavailability of some drugs may be increased due to absorption of drugs in oral cavity. Fast dissolving tablets of Metoprolol succinate prepared by sublimation method using camphor as subliming agent and croscarmellose sodium, sodium starch glycolate and crosspovidone as a super disintegrants by direct compression method. FTIR Spectroscopy was carried out to determine the suitability of superdisintegrants with the drug. The prepared fast dissolving tablets of Metoprolol succinate were evaluated for post compression parameters. Optimum formulation of Crosscarmalose sodium S3 showed disintegration time of 9 seconds and 97.07% of drug release.

Key words: Mouth dissolving tablet, Sublimation technique, Metoprolol succinate, Subliming agent, Superdisintegrants.

ABSTRACT

In the current scientific scenario the drug delivery technology has become highly competitive and rapidly evolving with ever increasing demand. Fast dissolving film (FDF) is one such type of an innovative and unique drug delivery system which is gaining much attention in the research field of rapid dissolving technology.  FDFs are the most advanced form of oral solid dosage form due to more flexibility, comfort and acceptability. They improve the efficacy of APIs by instantly wetting with saliva due to presence of hydrophilic polymer; thereby the film rapidly gets hydrated and dissolves to release the medication within few seconds as compared to fast dissolving tablets, without chewing and no need of water for administration. These drug delivery systems allow the medication to bypass the hepatic first pass metabolism thereby increasing the bioavailability of the drug. These films have a potential to deliver the drug systemically through intragastric, sublingual or buccal route of administration and also has been used for local action. FDFs offers a convenient way of dosing medication, not to special population groups like pediatric, geriatric, bedridden patients, mentally ill patients, but also to the general population thus can be considered as a versatile drug delivery system.

Key words: Fast Dissolving Film, Oral Cavity, Rapid Dissolving.

ABSTRACT

                Etodolac has been shown to have potent analgesic and anti-inflammatory activities similar to indomethacin and diclofenac and due to its preferential Cox-2 blockade; it has a better safety than conventional Non steroidal anti-inflammatory drug (NSAIDs) with respect to adverse effect on gastrointestinal and cardiovascular systems. Etodolac is superior to other NSAIDs as it has selectivity for Cox-2, a beneficial Cox inhibitor is well tolerated, has better Gastrointestinal (GI) tolerability and improved cardiovascular safety when compared with other selective Cox-2 inhibitor. To provide the patient with the most convenient mode of administration, there is need to develop a fast-disintegrating dosage form, particularly one that disintegrates and dissolves/disperses in saliva and can be administered without water, anywhere, any time. Such tablets are also called as “melt in mouth tablet.” Direct compression, freeze drying, sublimation, spray drying, tablet molding, disintegrant addition and use of sugar-based excipients are technologies available for mouth-dissolving tablet. Mouth-dissolving tablets of Etodolac were prepared with direct compression, in which different formulations were prepared with varying concentration of excipients. These tablets were evaluated for their friability, hardness, wetting time and disintegration time; the drug release profile was studied in buffer Phosphate Saline. F6 batch with crosprovidone with mannitol showed more release than other formulations and better results. The F6 batch of mouth dissolving tablets was found to be 98% drug release in 30 minutes. The F6 was the best of all nine formulations of mouth dissolving tablets of etodolac. Bioavailability of etodolac can be increased by formulating it as a mouth dissolving tablets.

Key words: Etodolac, Crospovidone, Sodium Starch Glycolate, Cross Carmellose Sodium, Mannitol, Mouth dissolving tablets.

ABSTRACT

The purpose of the present study is to investigate the acute oral toxicity and anti-ulcerogenic activities of the ethanol Extract of Barringtonia acutangula (EBA) leaf extract in albino rats. Study on acute toxicity of extract found to be safe at the doses 2000mg/kg body weight orally as per OECD guidelines No.423. EBA at the doses of 200 and 400 mg/kg body weight orally was administered to evaluate anti-ulcer activity by using indomethacin and cold-restraint stress induced gastric ulcer models in Albino rats. Ethanol Extract of Barringtonia acutangula dose dependent inhibition in indomethacin induced gastric lesions, and it also dose dependent inhibition in Cold-restraint stress induced gastric lesions. All the results are found to be statistically significant (p≤0.05). Hence we suggest that Ethanol Extract of the fruits of Barringtonia acutangula possess anti-ulcerogenic properties that may be due to cytoprotective mechanism.

Key words: Barringtonia acutangula, Anti-ulcer activity, Indomethacin, Cold-restraint stress.