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Nifedipine is a medication used to manage angina, high blood pressure, Raynaud's phenomenon, and premature labor. It is one
of the treatments of choice for Prinzmetal angina. It may be used to treat severe high blood pressure in pregnancy. Its use in
preterm labor may allow more time for steroids to improve the baby's lung function and provide time for transfer of the mother
to a well-qualified medical facility before delivery. In the present work, an attempt has been made to develop Sublingual tablets
of Nifedipine chitosan, Locust bean gum and crospovidone were employed as super disintegrating agents to enhance the
solubility and dissolution rate of selected drug molecule. All the formulations were prepared by direct compression method
using 6mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed good flow properties
such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and
they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations NDPN4 formulation
showed maximum % drug release i.e., 98.73 % in 8 min hence it is considered as optimized formulation. The NDPN4
formulation contains locust bean gum as super disintegrate in the concentration of 15 mg
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In the pharmaceutical industry, the layout of a manufacturing plant plays a crucial role in arranging physical facilities, including
equipment, workspaces, and storage areas, to enhance efficiency and safety while minimizing costs and waste. The design of
these layouts is pivotal for optimizing operational effectiveness, meeting regulatory standards, and improving product quality.
This review delves into the principles and types of layouts that are integral to successful pharmaceutical manufacturing. By
analyzing existing literature and industry practices, this study sheds light on essential design principles such as minimizing
movement, optimizing flow, utilizing space effectively, ensuring safety, and fostering flexibility, interdependence, and overall
integration. Various layout configurations, such as product layout, process layout, fixed-position layout, and cellular layouts,
are examined for their benefits and challenges in the pharmaceutical sector. Insights reveal that a thoughtfully designed plant
layout can significantly lower production costs, reduce material handling, and improve product quality through streamlined
workflows and adherence to Good Manufacturing Practices (GMP). Moreover, flexible, and integrated layout designs offer the
advantage of scalability and innovation, enabling manufacturers to adapt to market demands and technological progress.
Aligning layout design with industry best practices and technological advancements allows manufacturers to optimize resource
use, ensure high product quality, and maintain a competitive edge in a rapidly changing industry. The topic highlights the
ongoing need for research and development in layout design to address emerging challenges and opportunities in
pharmaceutical production
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